Program in Complex Trait Genomics, University of Queensland
We combine laboratory and computing expertise to generate high quality genomic data, and provide innovative data management solutions, to advance understanding of common complex diseases and benefit those affected by them.
The Human Studies Unit is part of the Program in Complex Trait Genomics based at the Institute of Molecular Bioscience, University of Queensland. It comprises highly skilled laboratory, project management and research IT staff working together to deliver a complete solution for the receipt, processing, sequencing, storage and dissemination of biological samples and genomic data.
Starting August 2nd, 475 DNA samples have been genotyped on Illumina® OmniExpress-24 BeadChips as part of the endometriosis disease stratification and risk prediction project. DNA samples originated from the Reproductive Sciences Laboratory at the San Raffaele Scientific Institute in Milan, Italy, and The Royal Women’s Hospital in Melbourne, Australia. This project introduced a new Illumina beadchip into our lab and we are happy to report pass rates of >98% for all samples.
30 June 2019
We have completed the whole genome methylation screening of our Autism CRC cohort. We processed 475 samples using the Illumina Epic arrays in record time. We started 13 May 2019 and were all done by 28 June 2019 – 6 weeks running time allowing for time away on our HSU retreat.
17 June 2019
Last week the HSU team attended an overnight retreat on North Stradbroke Island. We each presented a short talk about our area of expertise, and we completed workshops on human ethics, project planning and data management. We also enjoyed watching the humpback whales on their annual migration past the island.
05 June 2019
Over the last 3 years, between 23/3/2016 and 31/5/2019 we have processed a total of 4286 blood, 759 stool, 660 hair, 1010 urine and 345 saliva samples across 12 projects. Our busiest month was April 2018 when we receipted and processed 211 blood, 56 stool, 90 hair and 29 saliva samples.
31 May 2019
The 2015 – 2019 SALSA project funded by the MND Australia Ice Bucket Challenge Grant came to an end today. During the project we deposited blood samples from 651 MND cases, 230 controls, a total of 1967 sample collections and storage of > 22,000 sample aliquots. The work of the SALSA project will be continued by the NHMRC Partnership Grant.
30 April 2019
During the first quarter of 2019 we receipted and processed 214 blood, 81 stool, 44 urine and 44 saliva samples across seven research projects.
18 April 2019
We have just completed a GWAS (Genome-Wide Association Study) for Endometriosis, using samples from 3 Endometriosis projects. In total we processed 553 samples with an Average Call Rate of 0.99 (range 0.975-0.999).
31 January 2019
We have just completed a GWAS for Autism. We processed a total of 2490 samples.
31 December 2018
A total of 231 new SALSA participants were recruited into this project in 2018. 93 from Victoria, 61 from Queensland, 39 from Western Australia, 20 from South Australia and 18 from New South Wales.
28 September 2018
Our MND Cognition project was launched. This project is conducted by Prof. Gail Robinson and Amelia Ceslis through the RBWH MND Research Clinic under the direction of Dr. Robert Henderson.
Human Studies Research Unit,
Institute for Molecular Bioscience,
University of Queensland,
Brisbane St Lucia, QLD 4072